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KMID : 0191120140290091232
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Journal of Korean Medical Science
2014 Volume.29 No. 9 p.1232 ~ p.1239
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Epidemiological Aspects of Pertussis among Adults and Adolescents in a Korean Outpatient Setting: A Multicenter, PCR-Based Study
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Park Sung-hoon
Lee Sun-Hwa
Seo Ki-Hyun
Shin Kyeong-Cheol
Park Yong-Bum
Lee Myung-Goo
Yoo Kwang-Ha
Kim Hui-Jung
Park Jae-Seuk
Cho Jae-Hwa
Ko Yong-chun
Lee Soo-Keol
Cheon Ki-Tae
Kim Do-Il
Ha Jun-Wook
Lee Jae-Myung
Suhr Ji-Won
Jeong Eui-Hun
Jung Ki-Suck
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Abstract
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Epidemiological data of Bordetella pertussis infection among adolescents and adults are limited in Korea. Patients (≥ 11 yr of age) with a bothersome cough for less than 30 days were enrolled during a 1-yr period at 22 hospitals in Korea. Nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and for bacteriologic culture. In total, 490 patients were finally enrolled, and 34 (6.9%) patients tested positive for B. pertussis; cough duration (14.0 days [7.0-21.0 days]) and age distribution were diverse. The incidence was the highest in secondary referral hospitals, compared to primary care clinics or tertiary referral hospitals (24/226 [10.6%] vs. 3/88 [3.4%] vs. 7/176 [4.0%], P = 0.012), and the peak incidence was observed in February and August (15.8% and 15.9%), with no confirmed cases between March and June. In the multivariate analysis, post-tussive vomiting was significantly associated with pertussis (odds ratio, 2.508; 95% confidence interval, 1.146-5.486) and secondary referral hospital showed a borderline significance. In conclusion, using a PCR-based method, 6.9% of adolescent and adult patients with an acute cough illness had pertussis infection in an outpatient setting. However, hospital levels and seasonal trends must be taken into account to develop a better strategy for controlling pertussis.
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KEYWORD
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Pertussis, Adult, Hospitals, Incidence, Seasons
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